DMG-PEG2000

SKU: orb1218709

Description

DMG-PEG2000 is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

Key Properties

• CAS Number: 160743-62-4
• MW: 570.9
• Purity: >98% (HPLC)
• Formula: C₃₄H₆₆O₆
• Target: Others
• Solubility: DMSO:100 mg/mL (Need ultrasonic)

Bioactivity

• In Vivo:
  NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment. Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.
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• In Vitro:
  NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (~76% eGFP positive cells) is observed.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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