DMG-PEG 2000

SKU: orb1298372

Description

DMG-PEG2000 is a lipid-PEG conjugate used to formulate lipid nanoparticles (LNPs) for nucleic acid delivery. It enhances mucus penetration for oral plasmid DNA delivery in vivo and improves the transfection efficiency of siRNA-loaded liposomes in both in vitro and in vivo research applications.

Research Area

Metabolism Research

Key Properties

• CAS Number: 160743-62-4
• MW: 2526
• Purity: ≥98% (May vary between batches)
• Formula: (C₂H₄O)nC₃₂H₆₂O₅
• SMILES: N.CCCCCCCCCCCCCC(=O)OCC(COCCOC)OC(=O)CCCCCCCCCCCCC
• Target: Liposome,Others
• Solubility: Ethanol:100 mg/mL (39.59 mM);DMSO:60 mg/mL (23.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (0.79 mM)

Bioactivity

• In Vivo:
  METHODS: To study the permeability of NP-3, a single dose of NP-3 (150 μg DNA per mouse) was administered orally to mice. RESULTS: The NP-3 group maintained high luciferase expression in the liver, lung, and intestinal regions within 12 to 24 hours after administration. In addition, NP-3 showed a 1.5-fold higher signal intensity than the NP-1 or NP-2 groups within 12 to 24 hours after oral administration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

therapy, T2D, type II diabete, 293T, A549, DMG PEG 2000, DMGPEG 2000, DMG-PEG 2000, DMG-PEG2000, DMG-PEG-2000, HeLa, HepG2, Inhibitor, inhibit, lPEI/DNA nanoparticle, nucleic acid

Compound Identifiers

PubChem CID

155819508