DM3

SKU: orb1992881

Description

DM3 is a maytansinoid derivative featuring a disulfide or thiol linker, which functions as a potent tubulin polymerization inhibitor. It is widely employed as the cytotoxic payload in antibody-drug conjugates (ADCs) for targeted cancer therapy research, with applications in both in vitro cytotoxicity assays and in vivo xenograft model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 796073-54-6
• MW: 766.34
• Formula: C₃₇H₅₂ClN₃O₁₀S
• SMILES: [H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)\C=C/C=C(C)\Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)[C@]1(C)O[C@H]1[C@@H]2C
• Target: Microtubule Associated,ADC Cytotoxin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

154702829