DM3-BTA-14​​

SKU: orb3033134

Description

​​DM3-BTA-14​​ is a cationic lipid compound engineered for high-efficiency mRNA delivery developed by Hefei AlphaNA Biotechnology. Its structure features a rigid benzene-1,3,5-tricarboxamide core linked to a protonatable dimethylamino headgroup (-N(CH₃)₂) via a propylene spacer (-CH₂CH₂CH₂-) and two saturated C14 alkyl chains. This design enables ≈90% endosomal escape efficiency , superior lymph node targeting for vaccines , and effective tumor-specific mRNA delivery . It outperforms benchmark lipids while maintaining low cytotoxicity, forming stable nanoparticles with cholesterol/DSPC/DSPE-PEG (50:39:10:1 ratio) for therapeutic applications.

Key Properties

• MW: 672.54
• Purity: >98%
• Formula: C₄₁H₇₂O₅N₂
• SMILES: CCCCCCCCCCCCCCOC(=O)C1=CC(C(=O)OCCCCCCCCCCCCCC)=CC(C(=O)NCCCNC)=C1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only