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DM1-SMe

SKU: orb1940448

Description

DM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.

Images & Validation

Key Properties

CAS Number138148-68-2
MW784.38
Purity>98% (HPLC)
FormulaC36H50ClN3O10S2
SMILESCO[C@@H]1\C=C/C=C(C)/Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCSSC)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
TargetMicrotubule/Tubulin
SolubilityIn Vitro: DMSO : 100 mg/mL (127.49 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • DM1-SMe [orb1705074]

    96.00% (May vary between batches)

    138148-68-2

    784.38

    C36H50ClN3O10S2

    1 ml x 10 mM (in DMSO), 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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DM1-SMe (orb1940448)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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200 mg
500 mg
5 mg
$ 210.00
10 mg
$ 320.00
25 mg
$ 710.00
50 mg
$ 1,040.00
100 mg
$ 1,480.00