DM1-SMe

SKU: orb1705074

Description

DM1-SMe (DM1-SSMe) is a highly potent maytansinoid microtubule inhibitor, demonstrating 3-10 times greater potency than Maytansine with IC50 values ranging from 0.003 to 0.01 nM in human tumor cell lines. This small molecule is a valuable research tool for investigating tubulin-targeting agents in both in vitro cytotoxicity assays and in vivo preclinical cancer models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 138148-68-2
• MW: 784.38
• Purity: 96.00% (May vary between batches)
• Formula: C₃₆H₅₀ClN₃O₁₀S₂
• SMILES: [H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(C\C(C)=C/C=C\[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)[C@H]2C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCSSC
• Target: Microtubule Associated,ADC Cytotoxin
• Solubility: DMSO:60 mg/mL (76.49 mM);H2O:Insoluble;10% DMSO+90% Corn Oil:2.5 mg/mL (3.19 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tumor cell, ADC Payload, ADCCytotoxin, ADC Cytotoxin, antibody-drug conjugate, anti-tumor activity, DM1 SMe, DM1SMe, DM-1-SMe, DM1-SMe, DM1-SSMe, inhibit, Microtubule Associated, microtubule, Microtubule/Tubulin, MicrotubuleAssociated, maytansinoid, Inhibitor

Compound Identifiers

PubChem CID

131873213