DM-4 Antibody

SKU: orb3158131

Description

DM4 (also known as ravtansine or soravtansine) is a maytansinoid derivative that serves as a potent cytotoxic payload in antibody-drug conjugates (ADCs). It functions by inhibiting tubulin polymerization, arresting cell division, and inducing apoptosis in tumor cells. Structurally modified from DM1, DM4 enhances conjugation compatibility with linkers and has been used in several clinical ADC drugs, including mirvetuximab soravtansine for ovarian cancer treatment.

Images & Validation

• Reactivity: Rabbit

Key Properties

• Host: Human
• Clonality: Monoclonal
• Target: DM-4
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DM-4