DKM 2-93

SKU: orb1299840

Description

DKM 2-93

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 65836-72-8
• MW: 243.69
• Purity: 98.43%
• Formula: C₁₁H₁₄ClNO₃
• SMILES: COC1=C(OC)C=C(CNC(=O)CCl)C=C1
• Target: E1/E2/E3 Enzyme
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.41 mM);DMSO:150 mg/mL (615.54 mM)

Bioactivity

• Target IC50:
  UBA5:430 μM
• In Vitro:
  Covalent li and DKM 2-93 that impairs pancreatic cancer cell survival and in vivo tumor growth through covalently modifyin the catalytic cysteine o the ubiquitin-like modifier activating enzyme 5 (UBA5), thereby inhibiting its activity as a protein that activate the ubiquitin-like protein UFM1 to UFMylate proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme, E2 conjugating enzyme, E3 Enzyme, E2Enzyme, DKM 2 93, DKM 293, DKM 2-93, inhibit, E3 ligating enzyme, E3Enzyme, Inhibitor, Ubiquitin ligase, Ubiquitin conjugating enzyme, UBA5, Ubiquitin activating enzyme

Compound Identifiers

PubChem CID

2392259