DKM 2-93

SKU: orb1220360

Description

DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).

Key Properties

• CAS Number: 65836-72-8
• MW: 243.69
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₄ClNO₃
• SMILES: COc1ccc(CNC(=O)CCl)cc1OC
• Target: E1
• Solubility: DMSO:150 mg/mL (615.54 mM)

Bioactivity

• In Vivo:
  DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells In vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
• In Vitro:
  Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

E1