DKK1 (N) Antibody, Rabbit Polyclonal

SKU: orb67138

Description

Rabbit polyclonal to DKK1.Dickkopf-related protein 1 (DKK1) belongs to the dickkopf family. DKK1 is a secreted protein thatinduces anterior development by antagonizing canonical Wnt signaling upstream of its effect on betacateninregulation. DKK1 inhibits LRP5/6 interaction with Wnt and by forming a ternary complex withthe transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play animportant role in vertebrate development, where they locally inhibit Wnt regulated processes such asantero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult,Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Research Area

Developmental Biology, Epigenetics, Neuroscience, Signaling Pathways, Stem Cells, Wnt

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:1000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human DKK1
• Molecular Weight: 27
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-DKK1 antibody,anti-Dickkopfrelated protein 1 antibody,anti-Dickkopf1 antibody,anti-Dkk1 antibody,anti-hDkk1 antibody,anti-SK antibody

Western blot analysis of total cell extracts from human HepG2 using DKK1 antibody

Quick Database Links

UniProt

O94907