Digitonin

SKU: orb1226983

Description

Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant Digitalis purpurea. It's aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids.

Key Properties

• CAS Number: 11024-24-1
• MW: 1229.34
• Purity: >98% (HPLC)
• Formula: C₅₆H₉₂O₂₉
• SMILES: C[C@@H]1CC[C@]2(O[C@H]3[C@H]([C@H]4[C@@H]5CC[C@H]6C[C@H]([C@@H](C[C@@]6([C@H]5CC[C@@]4([C@H]3[C@@H]2C)C)C)O)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O[C@@H]9O[C@@H]([C@@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)O)CO)O[C@@H]%11OC[C@H]([C@@H]([C@H]%11O)O)O)O)CO)CO)O)OC1
• Target: Others
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg.
• In Vitro:
  Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Digitin | NSC 23471 | NSC 237417

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