DHODH-IN-3

SKU: orb1709879

Description

DHODH-IN-3 is a potent and selective inhibitor of human dihydroorotate dehydrogenase (HsDHODH), exhibiting an IC50 of 261 nM and binding with a Kiapp of 32 nM at the ubiquinone site. This compound shows promise as an antimalarial agent, supported by its activity in both enzymatic and cellular assays relevant to parasite proliferation.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1148126-04-8
• MW: 312.75
• Formula: C₁₇H₁₃ClN₂O₂
• SMILES: ClC=1C=C(C=CC1NC(/C(=C(/C)\O)/C#N)=O)C2=CC=CC=C2
• Target: Dehydrogenase,DNA/RNA Synthesis,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

54727984