Desogestrel

SKU: orb1300437

Description

Desogestrel is a synthetic progestin commonly utilized in combined oral contraceptives. In research, it is applied in pharmacological studies to investigate progestogenic activity and mechanisms in both in vitro receptor assays and in vivo models of reproductive endocrinology.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54024-22-5
• MW: 310.47
• Purity: 99.96% (May vary between batches)
• Formula: C₂₂H₃₀O
• SMILES: [H][C@@]12CC[C@@](O)(C#C)[C@@]1(CC)CC(=C)[C@]1([H])[C@@]3([H])CCCC=C3CC[C@@]21[H]
• Target: Progesterone Receptor|||Estrogen/progestogen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.22 mM);Ethanol:58 mg/mL (186.81 mM);DMSO:58 mg/mL (186.81 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Desogestrel is extensively metabolized after oral administration to rats and dogs; In rats, desogestrel is metabolized mainly at the C3, C5, C11, and C15 positions. An hydroxy group is introduced at the 15α-position of desogestrel, followed by conjugation with glucuronic acid. In dogs, desogestrel is mainly metabolized at the C3- and C17-positions.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Progesterone Receptor, ProgesteroneReceptor, progestogen Receptor, progestogenReceptor, PR, Org2969, Org-2969, Org 2969, Inhibitor, NR3C3, inhibit, EstrogenReceptor, Estrogen Receptor, ER, Cerazette, Desogen, Desogestrel, Desogestrelum

Compound Identifiers

PubChem CID

40973