Etonogestrel

SKU: orb1941033

Description

Etonogestrel is a steroidal progestin used in hormonal contraceptives.(In Vitro):Etonogestrel inhibits fertility by inhibiting the release of luteinizing hormone (LH), one of the reproductive hormones important in ovulation.Etonogestrel also increases the viscosity of cervical mucus, which hinders the passage of spermatozoa and alters the lining of the uterus to prevent implantation of a fertilized egg into the endometrium.Etonogestrel, a progestin, is a substrate of the CYP 3A4 oxidase system.Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).

Key Properties

• CAS Number: 54048-10-1
• MW: 324.46
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₈O₂
• SMILES: CC[C@]12CC(=C)[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
• Target: Estrogen Receptor/ERR
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  Etonogestrel inhibits fertility by inhibiting the release of luteinizing hormone (LH), one of the reproductive hormones important in ovulation. Etonogestrel also increases the viscosity of cervical mucus, which hinders the passage of spermatozoa and alters the lining of the uterus to prevent implantation of a fertilized egg into the endometrium. Etonogestrel, a progestin, is a substrate of the CYP 3A4 oxidase system. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs). Western blot analysis. Cell line: Human endometrial stromal cells (HESCs). Concentration: 100 nM. Incubation time: 24 hours. Result: Increased FKBP51 mRNA and protein levels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ORG 3236 | 3-keto Desogestrel | 3-oxo Desogestrel

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR