Deoxypodophyllotoxin

SKU: orb1297562

Description

Deoxypodophyllotoxin is a bioactive small molecule with demonstrated cytotoxic, antitumor, and anti-angiogenic properties. It functions as a vascular disrupting agent and tubulin polymerization inhibitor, supporting its investigation in cancer research using both in vitro cell-based assays and in vivo tumor model studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 19186-35-7
• MW: 398.41
• Purity: 99.21% (May vary between batches)
• Formula: C₂₂H₂₂O₇
• SMILES: [H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1C2
• Target: Microtubule Associated|||Apoptosis|||Autophagy
• Solubility: DMSO:55 mg/mL (138.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.02 mM)

Bioactivity

• In Vitro:
  Deoxypodophyllotoxin (DPT) induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS). DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation. Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability. Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT. Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caspase, Deoxypodophyllotoxin, Bcl-2, Autophagy, Apoptosis, MicrotubuleAssociated, microtubule, Microtubule/Tubulin, Microtubule Associated, PARP, inhibit, Inhibitor

Compound Identifiers

PubChem CID

345501