Deoxyandrographolide

SKU: orb1296123

Description

Deoxyandrographolide enhances NGF-mediated neurite outgrowth and inhibits the release of pro-inflammatory cytokines TNF-α and IL-6. This dual activity makes it a useful research tool for neuroinflammation and neuroregeneration studies in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 79233-15-1
• MW: 334.45
• Purity: 99.67%
• Formula: C₂₀H₃₀O₄
• SMILES: [H][C@]12CCC(C)=C(CCC3=CCOC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
• Target: Interleukin,TNF,IL Receptor
• Solubility: DMSO:10 mg/mL (29.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.99 mM)

Bioactivity

• In Vivo:
  The protective effect of 14-DAG against ethanol-induced hepatic injury is based on its ability to reduce oxidative stress through cNOS dependent improvement of redox status. 14-DAG mediated activation of adenylate cyclase-cAMP signaling leading to the up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism .
• In Vitro:
  Treatment with 14-deoxyandrographolide (14-DAG) activated AMPK through induction of cyclic AMP-protein kinase A pathway . 14-DAG down-regulated the formation of a death-inducing signaling complex, resulting in the desensitization of hepatocytes to TNF-alpha-induced apoptosis. Pretreatment of hepatocytes with 14-DAG accentuated microsomal Ca-ATPase activity through induction of NO/cGMP pathway . 14-DAG, in concentrations between 10-100 μM, reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner. In addition, 14-DAG reduced PAF-induced calcium flux in the presence of extracellular calcium, and tyrosine phosphorylation of a 44 kDa protein corresponding to the MAPK(ERK1) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ILReceptor, IL-6, IL Receptor, mRNA, neurite, LPS, mediators, levels, 14-deoxyandrographolide, Deoxyandrographolide, proinflammatory, TNF-α, outgrowth

Compound Identifiers

PubChem CID

21679042