Dendrid

SKU: orb1224732

Description

Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.

Key Properties

• CAS Number: 54-42-2
• MW: 354.1
• Purity: >98% (HPLC)
• Formula: C₉H₁₁IN₂O₅
• SMILES: O=C1NC(C(I)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O
• Target: Antifection
• Solubility: DMSO: 35 mg/mL (98.84 mM)

Bioactivity

• In Vivo:
  Animal model: C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months. Dosage: 50-200 mg/kg. Administration: Intraperitoneal injection, 3 times, 3 hours interval. Result: Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
• In Vitro:
  Cell Proliferation Assay Cell line: Crandell-Reese feline kidney (CRFK) cells. Concentration: 2-10 μM. Incubation time: 72 hours. Result: Showed the IC50 value of 4.3 μM. Cell Cytotoxicity Assay Cell line: Crandell-Reese feline kidney (CRFK) cells. Concentration: 5-50 μM. Incubation time: 72 hours. Result: Reduced by 10.8% relatively in CRFK cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-iodo-2′-deoxyuridine | NSC 39661 | SKF 14287

Quick Database Links

Gene Symbol

Antifection