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Demecolcine

SKU: orb1218001

Description

Demecolcine is an inhibitor of microtubule polymerization. It used to study embryonic cloning.

Images & Validation

Key Properties

CAS Number477-30-5
MW371.43
Purity>98% (HPLC)
FormulaC21H25NO5
SMILESO=C1C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
TargetMicrotubule/Tubulin
SolubilityIn Vitro: DMSO : 25 mg/mL (67.31 mM)

Bioactivity

In Vivo
Animal model: Mice. Dosage: 0.3 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Elevated 7.8-8-fold of the hypoploid and hyperploid frequencies in metaphase II cells relative to controls.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Colcemid | C-12669 | C 12669 | C12669 | Kolchicin | NSC-3096

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    477-30-5

    371.43

    C21H25NO5

    1 mg, 1 ml x 10 mM (in DMSO), 25 mg, 50 mg, 100 mg, 5 mg, 10 mg
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Protocol Information

Demecolcine (orb1218001)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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100 mg
200 mg
500 mg
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 330.00
50 mg
$ 470.00