Colcemid

SKU: orb1306915

Description

Colcemid (NSC-3096) is a tubulin-targeting agent that inhibits microtubule polymerization with an IC50 of 2.4 µM. This activity induces apoptosis, making it a valuable tool for cancer research and cellular studies in vitro, including investigations into cell cycle arrest and aneuploidy.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 477-30-5
• MW: 371.43
• Purity: 99.83% (May vary between batches)
• Formula: C₂₁H₂₅NO₅
• SMILES: COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)NC)=C3)=CC=C(OC)C3=O
• Target: Apoptosis,Microtubule Associated
• Solubility: DMSO:55 mg/mL (148.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM)

Bioactivity

• Target IC50:
  HepG2 cells:0.09 μM (EC50)|NCI-H460 cells:0.69 μM (EC50)|MCF-7 cells:0.6 μM (EC50)|tubulin:2.4 μM (EC50)|SF-268 cells:6.2 μM (EC50)

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tumor, Inhibitor, inhibit, NSC 3096, NSC3096, NSC-3096, Kolchicin, mitotic, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, metaphase, C12669, C-12669, C 12669, cancer, apoptosis, Colcemid, Demecolcine, derivative

Compound Identifiers

PubChem CID

2832