Demeclocycline

SKU: orb1707758

Description

Demeclocycline is a tetracycline antibiotic derived from Streptomyces aureofaciens. It exhibits antimicrobial properties and functions as a vasopressin antagonist, inducing nephrogenic diabetes insipidus. This makes it a research tool for studying renal physiology, water balance disorders, and modeling acute renal failure in experimental settings.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127-33-3
• MW: 464.85
• Purity: 98.25% (May vary between batches)
• Formula: C₂₁H₂₁ClN₂O₈
• SMILES: [H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c1c(O)ccc(Cl)c1[C@H]2O
• Target: Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.15 mM);DMSO:10 mg/mL (21.51 mM);H2O:20 mg/mL (43.02 mM)

Bioactivity

• In Vivo:
  Demeclocycline (40 mg/kg; intraperitoneal injection; once daily; for 48 hours) resulted in increased urine volume, decreased urine osmolality, and significantly increased fractional excretion of water.
  Read more...
• In Vitro:
  Demeclocycline (10 μM; 24 h) is a novel BTICs growth inhibitor, which can directly stimulate the activity of monocytes and macrophages.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ledermycin, Deganol, Demeclocycline, Declostatin, Deteclo, Antibacterial, Bioterciclin

Compound Identifiers

PubChem CID

54680690