Dehydroglyasperin C

SKU: orb3054694

Description

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive.

Key Properties

• CAS Number: 199331-35-6
• MW: 354.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₅
• Target: Akt
• Solubility: DMSO : 100 mg/mL (282.17 mM; ultraphonic; )

Bioactivity

• In Vivo:
  In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression.
• In Vitro:
  Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF. Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC). Cell Cycle Analysis Cell line: Human aortic smooth muscle cells (HASMC). Concentration: 0.1 μM, 0.5 μM, 1 μM Incubation time: 24 hours. Result: Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle. Western blot analysis. Cell line: Human aortic smooth muscle cells (HASMC). Concentration: 0.1 μM, 0.5 μM, 1 μM Incubation time: 24 hours. Result: Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Akt