Dehydroevodiamine

SKU: orb1221889

Description

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

Key Properties

• CAS Number: 67909-49-3
• MW: 301.34
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₅N₃O
• SMILES: CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3
• Target: Dopamine Receptor
• Solubility: In Vitro: DMSO : 8.33 mg/mL (27.64 mM)

Bioactivity

• In Vitro:
  Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expressionand prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression. Western blot analysis. Cell line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM. Incubation time: pretreated 2 hours. Result: Reduced iNOS and COX-2 expression and increased IκB-α expression. RT-PCR Cell line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM. Incubation time: pretreated 2 hours. Result: Reduced iNOS and COX-2 mRNA expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dopamine Receptor