Dehydroevodiamine hydrochloride

SKU: orb1301553

Description

Dehydroevodiamine hydrochloride

Research Area

Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 111664-82-5
• MW: 337.8
• Purity: 99.91%
• Formula: C₁₉H₁₆ClN₃O
• SMILES: Cl.CN1C2=C3N=c4ccccc4=C3CCN2C(=O)c2ccccc12
• Target: PGE Synthase,COX,NO Synthase,NF-κB,Cholinesterase (ChE)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.96 mM);DMSO:37 mg/mL (109.53 mM)

Bioactivity

• In Vivo:
  Dehydroevodiaminehydrochloride has strong Protective effects against cognitive impairments through its antioxidant activity and Inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.
• Animal Research:
  The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement an the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model the cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models the results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorate the spatial memory impairment in the scopolamine-induced amnestic rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Dehydroevodiamine, Dehydroevodiamine Hydrochloride, Dehydroevodiamine hydrochloride, AChE, Inhibitor, inhibit

Compound Identifiers

PubChem CID

135393457