DEF6 (C1) Antibody, Rabbit Polyclonal

• Catalog Number: orb67082
• Category: Antibodies
• Description: Rabbit polyclonal to DEF6.Differentially expressed in FDCP 6 (DEF6) is also known as SWAP-70-like adapter of T-cells (SLAT), which is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF). DEF6 plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, and regulates cell morphology in cooperation with activated RAC1. DEF6 also plays a role in Th2 (T helper cells) development and/or activation by interfering with ZAP70 signaling. DEF6 is required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity. Defects in DEF6 results in spontaneous development of a lupus-like syndrome in aging female mice.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Mouse
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: C-terminal region of mouse DEF6
• UniProt ID: Q66JW3
• MW: 73
• Tested applications: WB
• Dilution range: WB:1:1000-1:3000
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-DEF6 antibody,anti-Differentially expressed i
• Note: For research use only

Western blot analysis of total cell extracts from mouse thymus using DEF6 antibody