Decursinol angelate

SKU: orb1297402

Description

Decursinol angelate is a bioactive small molecule with demonstrated anti-cancer and anti-inflammatory properties. It functions by inhibiting VEGF-induced angiogenesis via VEGFR-2 suppression and modulates key pathways like PI3K/AKT, ERK, and NF-κB. Its activity has been investigated in both in vitro and in vivo models for oncology and inflammation research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 130848-06-5
• MW: 328.36
• Purity: 99.93% (May vary between batches)
• Formula: C₁₉H₂₀O₅
• SMILES: C\C=C(\C)C(=O)O[C@H]1Cc2cc3ccc(=O)oc3cc2OC1(C)C
• Target: JNK|||PKC|||ERK|||VEGFR
• Solubility: DMSO:65 mg/mL (197.95 mM)

Bioactivity

• In Vitro:
  Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, Decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. Immunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation. Rather, transcriptional analysis revealed that decursin and Decursinol angelate improved wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Decursinol angelate, inhibit, JNK, Inhibitor, ERK, VEGFR, PKC, Protein kinase C

Compound Identifiers

PubChem CID

776123