DCC Antibody (Center)

SKU: orb30334

Description

Rabbit polyclonal antibody to DCC also known as Tumor suppressor protein DCC whose expression can be detected in the mucus but it is majorly expressive in the axons and intestine. It is found in the axon. It can perform various functions like exogenesis and neuron migration. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with the netrin ligand. Implicated as a tumor suppressor gene.

Research Area

Cell Biology, Neuroscience

Images & Validation

• Tested Applications: IHC-P, WB
• Dilution Range: WB: 1:1000, IHC-P: 1:10-50
• Reactivity: Mouse
• Predicted Reactivity: Rat

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB32203
• Immunogen: Synthetic Peptide
• Target: DCC
• Molecular Weight: 158457
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anti-DCC antibody, anti-Netrin receptor DCC antibody, anti-IGDCC1 antibody

DCC Antibody (Center) western blot analysis in mouse heart tissue lysates (35 ug/lane). This demonstrates the DCC antibody detected the DCC protein (arrow).

DCC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of DCC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Quick Database Links

Gene Symbol

DCC

UniProt

P43146

RefSeq (Protein):NP_005206.2