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dASK1

SKU: orb3135651

Description

dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3064086-31-0
MW800.77
FormulaC38H38F2N10O8
SMILESO=C(NC1=NC(=CC=C1)C2=NN=CN2C(C)C)C3=CC(NC(=O)CCC(=O)NCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)=C(F)C=C3F
TargetPROTACs,ASK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information