Danshensu

SKU: orb1221798

Description

Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.

Key Properties

• CAS Number: 76822-21-4
• MW: 198.17
• Purity: >98% (HPLC)
• Formula: C₉H₁₀O₅
• SMILES: c1cc(c(cc1C[C@H](C(=O)O)O)O)O
• Target: TNF
• Solubility: H2O : 6.2 mg/mL 31.29 mM

Bioactivity

• In Vivo:
  Animal model: Adult BALB/c mice (male, 6-8 weeks, 20±2 g). Dosage: 25, 50, 100 mg/kg. Administration: Oral administration (daily for 7 continuous days) or i. v. (once). Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation. Ameliorated inflammatory cytokines in serum and lung tissue.
• In Vitro:
  Cell Migration Assay Cell line: FaDu and Ca9-22 cells. Concentration: 25, 50, and 100 μM. Incubation time: 24 h. Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells. Western blot analysis. Cell line: FaDu and Ca9-22 cells. Concentration: 25, 50, and 100 μM. Incubation time: 24 h. Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell. Caused significant reduction in p38 phosphorylation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dan shen suan A | Salvianic acid A

Quick Database Links

Gene Symbol

TNF