DACH1 (C2) Antibody, Rabbit Polyclonal

SKU: orb67117

Description

Rabbit polyclonal to DACH1.Dachshund homolog 1 (DACH1) is a transcription factor involved in regulation of organogenesis. Itappears to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cellproliferation in myoblasts by SIX1 is switched to coactivation through recruient of EYA3 to the SIX1-DACH1 complex. DACH1 may act as a corepressor of SIX6 in regulating proliferation by directlyrepressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. It also inhibits TGFbetasignaling through interaction with SMAD4 and NCOR1 and binding to chromatin DNA via theDACHbox-N domain. Expression of DACH1 is lost in certain forms of metastatic cancer, and iscorrelated with poor prognosis.

Research Area

Developmental Biology, Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:1000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human DACH1
• Molecular Weight: 78.5
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-DACH1 antibody,anti-Dachshund homolog 1 antibody,anti-DACH antibody

Western blot analysis of total cell extracts from human MCF7 using DACH1 antibody

Quick Database Links

UniProt

Q9UI36