D-Glucose

SKU: orb1310199

Description

D-Glucose

Research Area

Metabolism Research

Key Properties

• CAS Number: 50-99-7
• MW: 180.16
• Purity: 99.64%
• Formula: C₆H₁₂O₆
• SMILES: [C@H]([C@@H]([C@H](C=O)O)O)([C@@H](CO)O)O
• Target: Endogenous Metabolite
• Solubility: H2O:33 mg/mL (183.17 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:240 mg/mL (1332.15 mM)

Bioactivity

• In Vivo:
  METHODS: For oral glucose tolerance test (OGTT), rats were starved for 6 h and orally administered MET (200 mg/kg) 1 h before glucose loading. Only distilled water was used a the Vehicle in the control group. Wistar rats were fed 50% D-Glucose solution (4 g/kg) and GK diabetic rats were fed at 50% D-Glucose solution (1 g/kg). All blood Samples were collected by tail flow 0-120 min after glucose administration and blood glucose was determined. Results: Rats receiving MET had a lower apical density of SGLT1 in the jejunum, lower levels of phosphorylated PKA substratee in enterocytes, and lower PGR compared to rats treated with excipients.
• In Vitro:
  METHODS: Differentiated Caco-2 cells were stimulated with D-Glucose (125-500 mM) for 5 min and serotonin levels were measured. Results: Caco-2 cells released 5 hydroxytryptamine in response to D-Glucose similar to enterochromaffin cells. In response to the highest tested concentration of 500 mM D-Glucose, 5 hydroxytryptamine levels in the supernatant of Caco-2 cells increased by 81. ± 5.0%. METHODS: Retinal endothelial cells were treated with D-Glucose (30 mM) for 7 days and cell viability was measured by MTT assay. Results the viability of endothelial cells exposed to high glucose was significantly reduced to 76. ± .6% o the control.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

D(+)-Glucose, D Glucose, Dextrose, DGlucose, D-Glucose, Inhibitor, inhibit, EndogenousMetabolite, Endogenous Metabolite, Glucose, Glucopyranose, Grape sugar

Compound Identifiers

PubChem CID

107526