D-alpha-Hydroxyglutaric acid disodium salt

SKU: orb1227099

Description

A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.

Key Properties

• CAS Number: 103404-90-6
• MW: 192.08
• Purity: >98% (HPLC)
• Formula: C₅H₆Na₂O₅
• SMILES: [O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
• Target: Histone Demethylase
• Solubility: H2O: ≥ 32 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D-2-HG | D-2-hydroxyglutarate

Quick Database Links

Gene Symbol

Histone Demethylase