D-α-Hydroxyglutaric acid disodium

SKU: orb1300436

Description

D-α-Hydroxyglutaric acid disodium

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 103404-90-6
• MW: 192.078
• Purity: 99.94% (May vary between batches)
• Formula: C₅H₆Na₂O₅
• SMILES: O=C([O-])[C@H](O)CCC([O-])=O.[Na+].[Na+]
• Target: mTOR,Endogenous Metabolite,Reactive Oxygen Species,ATPase,ROS
• Solubility: DMSO: < 1 mg/mL (insoluble or slightly soluble). H2O: 250.00 mg/mL (1301.55 mM).

Bioactivity

• Target IC50:
  α-ketoglutarate-dependent dioxygenase:0.628 mM(Ki)
• In Vitro:
  In U-87 mg cells, D-α-Hydroxyglutaric acid disodium acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. Besides, D-α-Hydroxyglutaric acid disodium inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing.
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• Cell Research:
  Cells are seeded in 12-well plates and, after overnight incubation, treated with the indicated concentrations of each compound. After harvesting, cells are stained with acridine orange (AO) and 4′,6-diamidino-2-phenylindole (DAPI). Cell number and viability are measured based on AO and DAPI fluorescence as measured by NC3000 following the manufacturer's instructions.(Only for Reference)
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Storage & Handling

• Storage: Powder: -20°C for 3 years. In solvent: -80°C for 1 year.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

competitor, CeKDM7A, D α Hydroxyglutaric acid disodium, D-α-Hydroxyglutaric acid, DαHydroxyglutaric acid disodium, D-α-Hydroxyglutaric acid disodium, Disodium (R)-2-Hydroxyglutarate, Disodium 2-Hydroxyglutarate, D-a-Hydroxyglutaric acid, D-a-Hydroxyglutaric acid disodium, D-alpha-Hydroxyglutaric acid, D-alpha-Hydroxyglutaric acid disodium, D-alpha-Hydroxyglutaric acid disodium salt, 5-methlycytosine, ATP Synthase, inhibit, mTOR, neurotoxic, Inhibitor, IDH1, IDH2, Mammalian target of Rapamycin, H3K27me2, H3K9me2, excitotoxic, EndogenousMetabolite, Endogenous Metabolite, α-ketoglutarate, α-KG, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

51051608