Cytochalasin H

SKU: orb1306319

Description

Cytochalasin H is a cell-permeable mycotoxin that potently inhibits actin polymerization by capping filament ends and preventing monomer addition. This mechanism makes it a valuable tool for studying cytoskeletal dynamics, cell motility, and morphology in both in vitro assays and cellular research.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 53760-19-3
• MW: 493.63
• Purity: 98.72%
• Formula: C₃₀H₃₉NO₅
• SMILES: [H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@@]11[C@H](OC(C)=O)\C=C\[C@](C)(O)C[C@@H](C)C\C=C\[C@@]1([H])[C@H](O)C(=C)[C@H]2C
• Target: Caspase,MMP,Antibiotic,Antibacterial,Bcl-2 Family,Apoptosis
• Solubility: DMSO:50 mg/mL (101.29 mM)

Bioactivity

• In Vitro:
  Cytochalasin H significantly inhibited angiogenesis in vitro and in vivo, and suppressed the hemoglobin content and HIF-1α and VEGF protein expression in xenografted NSCLC tissues of nude mice. Meanwhile, Cytochalasin H inhibited the secretion of VEGF protein and the expression of HIF-1α protein in A549 and H460 cells. Moreover, Cytochalasin H had a significant inhibitory effect on VEGF mRNA expression but had no effect on HIF-1α mRNA expression, and Cytochalasin H inhibited HIF-1α protein expression by promoting the degradation of HIF-1α protein in A549 and H460 cells. Additionally, CyH dramatically inhibited AKT, P70S6K, and ERK1/2 activation in A549 and H460 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate, Cytochalasin H, MMP-2

Compound Identifiers

PubChem CID

13892273