Cystamine

SKU: orb2901614

Description

Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

Key Properties

• CAS Number: 51-85-4
• MW: 152.28
• Purity: >98% (HPLC)
• Formula: C₄H₁₂N₂S₂
• SMILES: NCCSSCCN
• Target: Caspase
• Solubility: In Vitro: DMSO : 100 mg/mL (656.69 mM; Ultrasonic ) H2O : 100 mg/mL (656.69 mM; Ultrasonic)

Bioactivity

• In Vivo:
  Cystamine (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice. Animal model: R6/2 transgenic HD mice. Dosage: 112, 225 mg/kg. Administration: Intraperitoneal or oral, daily. Result: Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
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• In Vitro:
  Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione. Western blot analysis. Cell line: uman neuroblastoma SH-SY5Y cells. Concentration: 250, 500 μM. Incubation time: 0-16 h. Result: Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase