Cystamine

SKU: orb1707410

Description

Cystamine (2,2'-Disulfanediyldiethanamine) is a transglutaminase inhibitor that also suppresses caspase-3 activity (IC50 = 23.6 µM). It is utilized in research models of Huntington's disease, including both in vitro enzymatic assays and in vivo studies exploring neuroprotective mechanisms.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 51-85-4
• MW: 152.281
• Purity: 99.84% (May vary between batches)
• Formula: C₄H₁₂N₂S₂
• SMILES: NCCSSCCN
• Target: Glutaminase,Apoptosis,Caspase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (21.67 mM);DMSO:90 mg/mL (591.02 mM)

Bioactivity

• Target IC50:
  Caspase-3:23.6 μM
• In Vivo:
  In R6/2 transgenic HD mice, oral and intraperitoneal administration of Cystamine (112-225 mg/kg) reduces the levels of transglutaminase and N(Sigma)-(gamma-L-glutamyl)-L-lysin. Cystamine extends survival and improves body weight and motor performance.
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• In Vitro:
  In human neuroblastoma SH-SY5Y cells, Cystamine inhibits the MG132-mediated and H2O2-mediated activation of caspase-3 in a concentration-dependent manner. Cystamine (250 μM) robustly results in an increasement of the glutathione level.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cystamine, 2,2'-Disulfanediyldiethanamine, Alkyl-Chain, Caspase-3

Compound Identifiers

PubChem CID

2915