Cyproterone acetate

SKU: orb1309541

Description

Cyproterone acetate is a synthetic steroidal antiandrogen that binds and antagonizes the androgen receptor, inhibiting testosterone-sensitive cell growth. Its progestational activity suppresses pituitary LH secretion, lowering testicular androgen production. It is used in research on prostate cancer, androgen-dependent disorders, and endocrine mechanisms in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 427-51-0
• MW: 416.94
• Purity: 98.43% (May vary between batches)
• Formula: C₂₄H₂₉ClO₄
• SMILES: C[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@]5(OC(C)=O)C(C)=O)[H])[H])[H])[H])[H]
• Target: Androgen Receptor
• Solubility: DMSO:40 mg/mL (95.94 mM);Ethanol:10 mg/mL (23.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Androgen receptor:7.1 nM
• In Vivo:
  Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages
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• In Vitro:
  Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, Cyproterone 17-O-acetate, Cyproterone acetate, Cyproterone Acetate, Cyproterone, DR5, cancer, AndrogenReceptor, Androgen Receptor, Androcur, inhibit, hormonal, Inhibitor, steroid, tumorigenesis, prostate

Compound Identifiers

PubChem CID

9880