Cynarin

SKU: orb1300209

Description

Cynarin (1,5-Dicaffeoylquinic acid) is a bioactive compound with neuroprotective and antioxidant properties, functioning through GSK3β inhibition and Bcl-2/Bax pathway modulation. It is utilized in research areas such as neurodegeneration and oxidative stress, with applications in both cellular and animal model studies.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 30964-13-7
• MW: 516.45
• Purity: 99.88%
• Formula: C₂₅H₂₄O₁₂
• SMILES: O[C@@H]1C[C@](C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1O)(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
• Target: ROS,Reactive Oxygen Species,Antioxidant,Influenza Virus,Antiviral
• Solubility: DMSO:250 mg/mL (484.07 mM)

Bioactivity

• In Vitro:
  Cynarinhas protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion.Cynarindecreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, Influenza Virus, InfluenzaVirus, inhibit, Inhibitor, Antioxidant, Antiviral, 1,5-Dicaffeoylquinic acid, Cynarin, Cynarine, Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1R,​3R,​4S,​5R)​-

Compound Identifiers

PubChem CID

5281769