1,3-Dicaffeoylquinic acid

SKU: orb1301539

Description

Cynarin (1,3-Dicaffeoylquinic acid) is a natural compound exhibiting antioxidant and choleretic activities, with research indicating potential immunosuppressive properties. It is utilized in studies investigating liver function, oxidative stress, and immune modulation in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 19870-46-3
• MW: 516.45
• Purity: 98.81% (May vary between batches)
• Formula: C₂₅H₂₄O₁₂
• SMILES: O[C@@H]1C[C@@](C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
• Target: ROS,PI3K,Akt,Reactive Oxygen Species
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.87 mM);DMSO:240 mg/mL (464.71 mM)

Bioactivity

• In Vivo:
  CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
• Animal Research:
  The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA).

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,3-O-Dicaffeoylquinic acid, 1,3-Dicaffeoylquinic acid, 1,3Dicaffeoylquinic acid, 1,3 Dicaffeoylquinic acid, 1,5-Dicaffeoylquinic acid, Akt, Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1S,​3R,​4R,​5R)​-, CYNARIN, Inhibitor, inhibit, Phosphoinositide 3-kinase, Reactive Oxygen Species, PKB, ReactiveOxygenSpecies, PI3K, Protein kinase B

Compound Identifiers

PubChem CID

6474640