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CYM50358

SKU: orb1940194

Description

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.(In Vitro):N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.

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Key Properties

CAS Number1314212-39-9
MW389.28
Purity>98% (HPLC)
FormulaC20H18Cl2N2O2
SMILESCc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
TargetPLD1
SolubilityIn Vitro: DMSO : 125 mg/mL (321.11 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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CYM50358 (orb1940194)

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 290.00
25 mg
$ 610.00
50 mg
$ 890.00
100 mg
$ 1,250.00