CYM50358

SKU: orb1298078

Description

CYM50358 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) antagonist with an IC50 of 25 nM. This small molecule tool compound is used in research to investigate S1P4-mediated signaling in immunological and inflammatory processes, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1314212-39-9
• MW: 389.28
• Purity: 99.76% (May vary between batches)
• Formula: C₂₀H₁₈Cl₂N₂O₂
• SMILES: Cc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
• Target: LPL Receptor
• Solubility: DMSO:125 mg/mL (321.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.28 mM)

Bioactivity

• Target IC50:
  S1P4 receptor:25 nM
• In Vitro:
  N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Lysophospholipid Receptor, LPLReceptor, LPL Receptor, CYM 50358, CYM50358, CYM-50358, S1PR4

Compound Identifiers

PubChem CID

53358422