CVT-313

SKU: orb1223199

Description

CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT-313 has an IC50 of 0.5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT-313 had no effect on other, nonrelated ATP-dependent serine/threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 microM. CVT-313 is a promising candidate for evaluation in other disease models related to aberrant cell proliferation.

Key Properties

• CAS Number: 199986-75-9
• MW: 400.47
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₈N₆O₃
• SMILES: CC(C)n1cnc2c1nc(nc2NCc1ccc(cc1)OC)N(CCO)CCO
• Target: Endothelin Receptor
• Solubility: DMSO : ≥ 100 mg/mL; 249.71 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CVT-313 | CVT 313 | CVT313

Quick Database Links

Gene Symbol

Endothelin Receptor