CUL4A (N2) Antibody, Rabbit Polyclonal

SKU: orb66954

Description

Rabbit polyclonal to CUL4A.CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNAdamage-response proteins. CUL4A is a core component of multiple cullin-RING-based E3 ubiquitinproteinligase complexes which mediate the ubiquitination and subsequent proteasomal degradationof target proteins. As a scaffold protein, CUL4A may contribute to catalysis through positioning of thesubstrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complexis dependent on the neddylation of the cullin subunit. CUL4A may be involved in ubiquitination of JUN,P53, CDKN1B and HOXA9.

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human CUL4A
• Molecular Weight: 88
• Purity: Affinity purification

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-CUL4A antibody,anti-Cullin4A antibody

Western blot analysis of total cell extracts from human Hela(Lane1) and mouse testis(Lane2) using CUL4A antibody

Quick Database Links

UniProt

Q13619