CUL2 (N) Antibody, Rabbit Polyclonal

• Catalog Number: orb67162
• Category: Antibodies
• Description: Rabbit polyclonal to CUL2.Cullin-2 (CUL2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCSboxprotein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins.CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioningof the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of thecomplex is dependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. ECS(VHL) mediates the ubiquitination of hypoxiainduciblefactor (HIF).
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: N-terminal region of human CUL2
• UniProt ID: Q13617
• MW: 87
• Tested applications: WB
• Dilution range: WB:1:1000-1:5000
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-CUL2 antibody,anti-Cullin2 antibody,anti-CUL2
• Research Area: Epigenetics, Infectious Diseases
• Note: For research use only

Western blot analysis of total cell extracts from human Hela using CUL2 antibody