Cucurbitacin B

SKU: orb1304233

Description

Cucurbitacin B

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 6199-67-3
• MW: 558.70
• Purity: 99.08%
• Formula: C₃₂H₄₆O₈
• SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C
• Target: PTEN,HIF,COX,STAT,Integrin,HIF/HIF Prolyl-Hydroxylase,Apoptosis,Endogenous Metabolite,ROS Kinase,Autophagy
• Solubility: Ethanol:50.00 mg/mL (89.49 mM);Chloroform, Dichloromethane, Ethyl Acetate:Soluble;DMSO:144.00 mg/mL (257.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.00 mg/mL (7.16 mM)

Bioactivity

• In Vivo:
  In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels.
• In Vitro:
  Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation.
• Cell Research:
  For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cuc B, Cucurbitacin B, Endogenous Metabolite, DATISCACIN, Autophagy, Apoptosis, Amarine, Inhibitor, inhibit, EndogenousMetabolite, Integrin, HIF-1, PTEN, STAT3

Compound Identifiers

PubChem CID

2885