CTP Synthetase-IN-1

SKU: orb1744866

Description

CTP Synthetase-IN-1 is a potent, orally bioavailable dual inhibitor of human CTPS1 and CTPS2. It exhibits antitumor and anti-inflammatory activity, supporting its use in research models of cancer and inflammatory diseases like rheumatoid arthritis.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2338811-71-3
• MW: 512.53
• Purity: 98.11% (May vary between batches)
• Formula: C₂₀H₁₉F₃N₆O₃S₂
• SMILES: O=C(NC1=NC=C(C=C1)C2=NC(=CN=C2)C(F)(F)F)C(C=3N=C(SC3)NS(=O)(=O)C4CC4)(C)C
• Target: Others,DNA/RNA Synthesis
• Solubility: DMSO:80 mg/mL (156.09 mM)

Bioactivity

• Target IC50:
  CTPS2 (human):18 nM|CTPS1(human):32 nM
• In Vivo:
  In the Mouse collagen-induced arthritis (CIA) model, CTP Synthetase-IN-1 (10 mg/kg, p.o; twice daily; for 18 days) exhibited significant pharmacological responses.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CTP synthase

Compound Identifiers

PubChem CID

138674003