CTP Synthetase-IN-1 Ammonium salt

SKU: orb2283869

Description

CTP Synthetase-IN-1 Ammonium salt is a potent, orally bioavailable inhibitor of cytidine 5'-triphosphate synthetase (CTPS). It is a research tool for investigating CTPS function in antimicrobial, anti-inflammatory, and antitumor contexts, including in vitro studies relevant to viral infections like SARS-CoV-2.

Research Area

Cell Biology, Molecular Biology

Key Properties

• MW: 529.56
• Purity: 99.93% (May vary between batches)
• Formula: C₂₀H₂₂F₃N₇O₃S₂
• SMILES: O=C(C(C)(C)C1=CSC([N-]S(=O)(C2CC2)=O)=N1)NC3=NC=C(C4=NC(C(F)(F)F)=CN=C4)C=C3.[NH4+]
• Target: Others,DNA/RNA Synthesis
• Solubility: DMSO:80 mg/mL (151.07 mM)

Bioactivity

• Target IC50:
  CTPS1 (human):32 nM|CTPS2 (human):18 nM
• In Vivo:
  In the mouse collagen-induced arthritis (CIA) model, CTP Synthetase-IN-1 Ammonium salt (10 mg/kg and 50 mg/kg; oral administration, twice daily, for 18 days) was able to improve specific indicators of disease severity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CTPS-IN-1 Ammonium salt, CTPSynthetaseIN1Ammoniumsalt(2338811713Freebase), CTP Synthetase-IN-1 Ammonium salt(2338811-71-3 Free base), CTP synthase

Compound Identifiers

PubChem CID

172005479