CTLA-4 Antibody

SKU: orb2568772

Description

The CTLA-4 antibody (clone 9D9) is a monoclonal antibody that specifically targets the mouse CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152 [1]. CTLA-4 is a 33 kDa cell surface receptor, belonging to the CD28 family of the immunoglobulin superfamily. CTLA-4 plays a crucial role in immune regulation. 9D9 blocks the binding of murine CTLA-4-Ig to B7-1-positive cells [2]. It has an inhibitory effect and acts as an “off switch” for T cells. It binds to the ligands CD80 and CD86 on antigen-presenting cells (APCs) and thereby inhibits the activation of T cells . The CTLA-4 antibody clone 9D9 has been used to block CTLA-4 and has been shown to enhance T-cell immunity against tumors .

Images & Validation

• Tested Applications: In vivo
• Reactivity: Mouse
• Application Notes:
  Recomended Isotype: Mouse IgG2b k Isotype Control, Recomended Isotype Catalog: orb2568791

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: m IgG2b
• Clone No.: 9D9
• Immunogen: Unknown
• Target: CTLA-4
• Purity: ≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 1 mg/ mL
• Disclaimer: For research use only

Alternative Names

Anti-Mouse CTLA-4, CD152, CTLA4, cytotoxic T-lymphocyte-associated antigen 4, Cytotoxic T-lymphocyte protein 4,

Quick Database Links

Gene Symbol

CTLA-4

UniProt

P09793