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Crustecdysone

SKU: orb1304895

Description

Crustecdysone

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number5289-74-7
MW480.63
Purity99.67%
FormulaC27H44O7
SMILESCC(C)(O)CCC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C
TargetEndogenous Metabolite,Autophagy,Caspase
SolubilityEthanol:89 mg/mL (185.17 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM);DMSO:125 mg/mL (260.08 mM)

Bioactivity

In Vivo
In cells induced by CoCl2, 20 hydroxyecdysone reduce the production of Reactive oxygen species (ROS), diminishes mitochondrial membrane depolarization, and suppresse the release of cytochrome c int the cytoplasm, thereby ameliorating cell damage. In H4IIE cells, 20 hydroxyecdysone effectively lower the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), resulting in decreased glucose production.
In Vitro
In C57BL/6J mice fed a high-fat diet, oral administration of 20 hydroxyecdysone (10 mg/kg/day, for 13 weeks) was able to improve obesity and Insulin levels, reducing body weight and body fat content.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Caspase, Commisterone, Crustecdysone, arthropods, Autophagy, B-ecdysone, 20-Hydroxyecdysone, metamorphosis, EndogenousMetabolite, ecdysteroid, Ecdysterone, ecdysis, Ecdysone, Endogenous Metabolite, Hydroxyecdysone, α-Ecdysone

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Quality Guarantee

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Key Properties

No computed properties available.

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Crustecdysone (orb1304895)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 90.00
25 mg
$ 110.00
50 mg
$ 140.00
100 mg
$ 180.00
500 mg
$ 380.00
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