Crustecdysone

SKU: orb1304895

Description

Crustecdysone (Hydroxyecdysone) is a steroid hormone that controls molting (ecdysis) in insects. It is widely used in entomology and developmental biology research, both in vivo and in vitro, to study hormone signaling, gene regulation, and metamorphosis.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 5289-74-7
• MW: 480.63
• Purity: 99.67% (May vary between batches)
• Formula: C₂₇H₄₄O₇
• SMILES: CC(C)(O)CCC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C
• Target: Autophagy,Endogenous Metabolite,Caspase
• Solubility: Ethanol:89 mg/mL (185.17 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.16 mM);DMSO:125 mg/mL (260.08 mM)

Bioactivity

• In Vivo:
  In cells induced by CoCl2, 20-Hydroxyecdysone reduces the production of reactive oxygen species (ROS), diminishes mitochondrial membrane depolarization, and suppresses the release of cytochrome c into the cytoplasm, thereby ameliorating cell damage. In H4IIE cells, 20-Hydroxyecdysone effectively lowers the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), resulting in decreased glucose production.
• In Vitro:
  In C57BL/6J mice fed a high-fat diet, oral administration of 20-Hydroxyecdysone (10 mg/kg/day, for 13 weeks) was able to improve obesity and insulin levels, reducing body weight and body fat content.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caspase, Commisterone, Crustecdysone, arthropods, Autophagy, B-ecdysone, 20-Hydroxyecdysone, metamorphosis, EndogenousMetabolite, ecdysteroid, Ecdysterone, ecdysis, Ecdysone, Endogenous Metabolite, Hydroxyecdysone, α-Ecdysone

Compound Identifiers

PubChem CID

271605