Ecdysone

SKU: orb1682708

Description

Ecdysone is a key insect steroid hormone that induces apoptosis by activating the mineralocorticoid receptor. Its signaling via the Ecdysone receptor isoform B1 is cell-autonomously required for programmed muscle death, making it a critical tool for studying developmental biology and cell death mechanisms in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3604-87-3
• MW: 464.63
• Purity: 100.00% (May vary between batches)
• Formula: C₂₇H₄₄O₆
• SMILES: C[C@H]([C@@H](CCC(C)(C)O)O)[C@@H](CC1)[C@@](C)(CC[C@H]([C@@](C)(C[C@@H]2O)[C@H]3C[C@H]2O)C2=CC3=O)[C@]12O
• Target: Autophagy|||Apoptosis|||ATPase|||Glucocorticoid Receptor|||Potassium Channel|||Endogenous Metabolite|||Sodium Channel
• Solubility: DMSO:60 mg/mL (129.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.15 mM)

Bioactivity

• In Vivo:
  In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects.
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• In Vitro:
  Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α-Ecdysone, transitions, regulation, steroid, SodiumChannel, Sodium Channel, sleep, receptor, Potassium Channel, PotassiumChannel, coordinating, developmental, Crustecdysone, Autophagy, ATPase, Apoptosis, 20E, 20-hydroxyecdysone, Inhibitor, inhibit, mineralocorticoid, Mineralocorticoid Receptor, metabolite, homeostatic, hormone, Human Endogenous Metabolite, Glucocorticoid Receptor, GlucocorticoidReceptor, Ecdysone, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

171361473