Cortisone acetate

SKU: orb1224930

Description

Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester; the C21 acetate ester of cortisone and acts as a prodrug of cortisone in the body.Allergy Approved(In Vitro):Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).(In Vivo):Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-04-4
• MW: 402.4807
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₀O₆
• SMILES: CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
• Target: GR
• Solubility: DMSO: 6.8 mg/mL (Need ultrasonic and warming)

Bioactivity

• In Vivo:
  Cortisone (2 mg/kg; i. m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits. Animal model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion. Dosage: 2 mg/kg. Administration: Intramuscular injection on alternate days for 2 months. Result: Reduced the BCG lesions and tuberculin reactions. Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.
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• In Vitro:
  Cortisone (2.8-28, 000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cortisone 21-acetate

Quick Database Links

Gene Symbol

GR